More Sucharit Bhakdi MD, Karina Reiss PhD, and Michael Palmer MD 1. Rationale for development of vaccines The concept underlying vaccine development is straightforward: application of a harmless derivative of an infectious agent should stimulate the immune system to produce antibodies that protect against that agent. Introduction of any foreign substance into the body can never be entirely devoid of risks, however, so the prime … Continue reading Gene-based vaccination–quo vadis?